Circulating gamma-glutamyltransferase fractions in cirrhosis
نویسندگان
چکیده
منابع مشابه
Circulating gamma-glutamyltransferase fractions in cirrhosis.
BACKGROUND & AIMS Four gamma-gultamyltransferases (GGT) fractions (b-, m-, s-, and f-GGT) have been identified in human plasma and their concentrations and ratios vary in different pathological conditions. To assess the behaviour of fractional GGT in cirrhotic patients evaluated for liver transplantation. METHODS This was a single-centre, cross-sectional study; GGT fractions were determined b...
متن کاملDevelopmental variations of plasma gamma-glutamyltransferase fractions in humans and in laboratory mammalians.
Plasma samples from human cord blood, and fetuses, newborns, and adults of different mammalians species were analyzed by gel-filtration chromatography, to ascertain whether gamma-glutamyltransferase (GGT) fractions reflect liver maturation. Human cord blood plasma showed higher b-, m-, and s-GGT fraction as compared to adult women. In rat and mouse fetuses and in newborns, b-GGT was the most ab...
متن کاملMarkedly elevated gamma-glutamyltransferase.
Gamma-glutamyltransferase (GGT) is a highly sensitive but poorly specific liver enzyme commonly used to detect hepatobiliary disease and possible alcohol abuse. Isolated elevations of this enzyme may be due to biochemical anomalies rather than the presence of pathology.
متن کاملGamma-Glutamyltransferase Fractions in Human Plasma and Bile: Characteristic and Biogenesis
Total plasma gamma-glutamyltransferase (GGT) activity is a sensitive, non-specific marker of liver dysfunction. Four GGT fractions (b-, m-, s-, f-GGT) were described in plasma and their differential specificity in the diagnosis of liver diseases was suggested. Nevertheless fractional GGT properties have not been investigated yet. The aim of this study was to characterize the molecular nature of...
متن کاملCorrelates and reference limits of plasma gamma-glutamyltransferase fractions from the Framingham Heart Study.
BACKGROUND We assessed GGT fractions correlates and their reference values in the Offspring Cohort of the Framingham Heart Study. METHODS Correlates of GGT fractions were assessed by multivariable regression analysis in 3203 individuals [47% men, mean age (SD): 59 (10) years]. GGT fractions reference values were established by empirical quantile analysis in a reference group of 432 healthy su...
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ژورنال
عنوان ژورنال: Liver International
سال: 2014
ISSN: 1478-3223
DOI: 10.1111/liv.12455